Blar i NIBIO Brage på forfatter "Steen, Hege"
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Establishment of a piscine myocarditis virus (PMCV) challenge model and testing of a plant-produced subunit vaccine candidate against cardiomyopathy syndrome (CMS) in Atlantic salmon Salmo salar
Su, Hang; van Eerde, André; Steen, Hege; Heldal, Inger; Haugslien, Sissel; Ørpetveit, Irene; Wüstner, Stefanie Caroline; Inami, Makoto; Løvoll, Marie; Rimstad, Espen; Clarke, Jihong Liu (Peer reviewed; Journal article, 2021-08-30)Cardiomyopathy syndrome (CMS) is a severe cardiac disease occurring in the grow-out sea phase of farmed Atlantic salmon with approximately 100 outbreaks annually in Norway. Piscine myocarditis virus (PMCV) is believed to ... -
Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice
Dobrica, Mihaela-Olivia; van Eerde, André; Tucureanu, Catalin; Onu, Adrian; Paruch, Lisa; Caras, Iuliana; Vlase, Ene; Steen, Hege; Haugslien, Sissel; Alonzi, Dominic; Zitzmann, Nicole; Bock, Ralph; Dubuisson, Jean; Popescu, Costin-Ioan; Stavaru, Crina; Clarke, Jihong Liu; Branza-Nichita, Norica (Peer reviewed; Journal article, 2021-05-18)Chronic infection with hepatitis C virus (HCV) remains a leading cause of liver-related pathologies and a global health problem, currently affecting more than 71 million people worldwide. The development of a prophylactic ... -
In-depth characterization of Trichoderma reesei cellobiohydrolase TrCel7A produced in Nicotiana benthamiana reveals limitations of cellulase production in plants by host-specific post-translational modifications
van Eerde, André; Varnai, Aniko; Jameson, John-Kristian; Paruch, Lisa; Moen, Anders; Anonsen, Jan Haug; Chylenski, Piotr; Steen, Hege; Heldal, Inger; Bock, Ralph; Eijsink, Vincent; Clarke, Jihong Liu (Journal article; Peer reviewed, 2019)Sustainable production of biofuels from lignocellulose feedstocks depends on cheap enzymes for degradation of such biomass. Plants offer a safe and cost‐effective production platform for biopharmaceuticals, vaccines and ... -
Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination
Clarke, Jihong; Paruch, Lisa; Dobrica, Mihaela-Olivia; Caras, Iuliana; Tucureanu, Catalin; Onu, Adrian; Ciulean, Sonya; Stavaru, Crina; van Eerde, André; Wang, Yanliang; Steen, Hege; Haugslien, Sissel; Petrareanu, Catalina; Lazar, Catalin; Popescu, Costin-loan; Bock, Ralph; Dubuisson, Jean; Branza-Nichita, Norica (Journal article; Peer reviewed, 2017)The hepatitis C virus (HCV) is a major etiologic agent for severe liver diseases ( e.g . cirrhosis, fibrosis and hepatocellular carcinoma). Approximately 140 million people have chronic HCV infections and about 500 000 die ... -
Transcriptome profiling and in silico detection of the antimicrobial peptides of red king crab Paralithodes camtschaticus
Yakovlev, Igor; Lysøe, Erik; Heldal, Inger; Steen, Hege; Hagen, Snorre; Clarke, Jihong Liu (Peer reviewed; Journal article, 2020-07-29)Endogenous antimicrobial peptides (AMPs) are evolutionarily ancient factors of innate immunity, which are produced by all multicellular organisms and play a key role in their protection against infection. Red king crab ...